Which inflammatory lens condition can lead to secondary glaucoma through lens-induced uveitis?

Which inflammatory lens condition can lead to secondary glaucoma through lens-induced uveitis?

• A. Phacolytic lens-induced uveitis
• B. Immune-mediated uveitis
• C. Uveitis unrelated to lens
• D. Primary glaucoma

Answer: (A)

The main idea is that inflammation caused by leaked lens proteins from a compromised lens capsule can block the eye’s drainage pathways and raise intraocular pressure, producing secondary glaucoma. This happens most classically with phacolytic lens-induced uveitis, which occurs in hypermature cataracts. In this situation, proteins leak from the degraded lens into the anterior chamber, triggering an inflammatory response with macrophages loaded with lens protein. That inflammatory debris can clog the trabecular meshwork, leading to increased intraocular pressure and glaucoma changes. Other options describe uveitis or glaucoma not specifically tied to lens protein leakage, so they don’t explain a lens-driven mechanism for secondary glaucoma. Therefore, phacolytic lens-induced uveitis is the correct connection.

The main idea is that inflammation caused by leaked lens proteins from a compromised lens capsule can block the eye’s drainage pathways and raise intraocular pressure, producing secondary glaucoma. This happens most classically with phacolytic lens-induced uveitis, which occurs in hypermature cataracts. In this situation, proteins leak from the degraded lens into the anterior chamber, triggering an inflammatory response with macrophages loaded with lens protein. That inflammatory debris can clog the trabecular meshwork, leading to increased intraocular pressure and glaucoma changes. Other options describe uveitis or glaucoma not specifically tied to lens protein leakage, so they don’t explain a lens-driven mechanism for secondary glaucoma. Therefore, phacolytic lens-induced uveitis is the correct connection.